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KMID : 0364820110470010170
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Korean Journal of Microbiology
2011 Volume.47 No. 1 p.170 ~ p.173
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Conservation of the Epothilone-Biosynthetic Genes in Sorangium cellulosum Strains
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Hyun Dong-Gon
Youn Jin-kwon
Cho Kung-Yun
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Abstract
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The epothilone biosynthetic gene cluster (epoA~F, epoK) of Sorangium cellulosum KYC3013, an epothilone producing myxobacterium isolated in Korea, was cloned. When the amino acid sequences of the encoded proteins were compared with those from S. cellulosum SMP44, S. cellulosum So ce90, and S. cellulosum So0157-2, which were isolated in other continents or country, the proteins from different strains were 97.4-99.8% identical each other. This suggested that the pothilonebiosynthetic gene clusters are well conserved in S. cellulosum strains.
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KEYWORD
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Sorangium cellulosum, epothilone, epothilone biosynthetic gene, myxobacteria
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